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ALKALOIDS OF PICRALIMA NITIDA USED FOR TREATMENT OF PROTOZOAL DISEASE

A method of preparing substantially purified alkaloids from seeds, stems, uit-rind and bark of a plant selected from Picralima nitida, Gongronema latifolia, Dorstenia multiradiata, Cola attiensis, Rothmania withfieldii and Desmodium gangeticum, for use in the treatment of protozoal diseases, comprising:pulverizing said plant;a first solvent, drying the extracted material and re-extracting the dried material with a different solvent;extracting a fresh sample of said plant with boiling water;filtering and concentrating the boiling water solvent extracts under reduced pressure;concentrating the dried extract to a gum and re-extracting said gum with an aqueous acidic HCl solution;filtering the acidic extract and making it alkaline to a pH of about 9 with a concentration NaOH solution;extracting the alkaline solution with dichloromethane;concentrating organic layers of the extracted alkaline solution to dryness under reduced pressure to obtain an alkaloid fraction; andseparating the alkaloid fraction by liquid chromotography-mass spectrometry to obtain substantially purified alkaloids for use in treatment of protozoal diseases.


Docket:WRAIR 92-50

Publication/Issued No.:5,290,553

Publication/Issue Date:1994-03-01

Categories: Treatment

More Detail:Visit USPTO.GOVExternal link

Lab:WRAIR

Inventor(s):IWU, M.; KLAYMAN, D.; JACKSON, J.; TALLY, J.; ANDERSEN, S.

Abstract:Download


For Licensing Opportunities, please contact the ORTA at USArmy.Detrick.MEDCOM-USAMRMC.List.ORTA@mail.mil
 

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