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VACCINE AGAINST GRAM NEGATIVE BACTERIA
A mucosal vaccine for Neisseria based on native outer membrane vesicles (NOMV) prepared from genetically engineered vaccine strain and unexposed to detergents is described. Methods for extending this vaccine approach to other Gram negative bacteria are also decribed.
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Inventor(s):ZOLLINGER, W.; SHOEMAKER, D.; SAUNDERS, A.; BRANDT, B.