Technologies Available for Licensing
THERAPEUTIC TREATMENT AND PREVENTION OF INFECTIONS WITH A BIOACTIVE MATERIALS ENCAPSULATED WITHIN A BIODEGRADEABLE-BIOCOMPATIBLE POLYMERIC MATRIX
Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer, which may contain a pharmaceutically-acceptable adjuvant, as a blend of upcapped free carboxyl end group, and end-capped forms ranging in ratios from 100/0 to 1/99.
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Inventor(s):SETTERSTROM, J.; VAN HAMONT, J.; REID, R.; JACOB, E.; JEYANTHI, R.; BOEDECKER, E.; MCQUEEN, C.; JARBOE, D.; CASSELS, F.; BROWN, W.; THIES, C.; TICE, T.; ROBERTS, F.; FRIDEN, P.