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THERAPEUTIC TREATMENT AND PREVENTION OF INFECTIONS WITH A BIOACTIVE MATERIALS ENCAPSULATED WITHIN A BIODEGRADEABLE-BIOCOMPATIBLE POLYMERIC MATRIX

Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer, which may contain a pharmaceutically-acceptable adjuvant, as a blend of upcapped free carboxyl end group, and end-capped forms ranging in ratios from 100/0 to 1/99.


Docket:WRAIR 96-M10

Publication/Issued No.:6,844,010

Publication/Issue Date:2005-01-18

Categories: Treatment

More Detail:Visit USPTO.GOVExternal link

Lab:WRAIR

Inventor(s):SETTERSTROM, J.; VAN HAMONT, J.; REID, R.; JACOB, E.; JEYANTHI, R.; BOEDECKER, E.; MCQUEEN, C.; JARBOE, D.; CASSELS, F.; BROWN, W.; THIES, C.; TICE, T.; ROBERTS, F.; FRIDEN, P.

Abstract:Download


For Licensing Opportunities, please contact the ORTA at USArmy.Detrick.MEDCOM-USAMRMC.List.ORTA@mail.mil
 

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