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THERAPEUTIC TREATMENT AND PREVENTION OF INFECTIONS WITH A BIOACTIVE MATERIAL(S) ENCAPSULATED WITHIN A BIODEGRADABLE-BIO-COMPATIBLE POLYMERIC MATRIX

Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer having a molar composition of lactide/glycolide from 90/10 to 40/60, which may contain a pharmaceutically-acceptable adjuvant, as a blend of uncapped free carboxyl end group and end-capped forms ranging to ratios from 100/0 to 1/99.


Docket:WRAIR 96-M12

Publication/Issued No.:6,902,743

Publication/Issue Date:2005-06-07

Categories: Vaccine

More Detail:Visit USPTO.GOVExternal link

Lab:WRAIR

Inventor(s):SETTERSTROM, J.; TICE, T., JACOB, E., REID, R.; VAN HAMMONT, J.; BOEDECKER, E., JEYANTHI, R.; FRIDEN, P.; ROBERTS, D.; MCQUEEN, C.; BHATTACHARJEE, A.; CROSS, A.; SADOFF, J; ZOLLINGER, W.


For Licensing Opportunities, please contact the ORTA at USArmy.Detrick.MEDCOM-USAMRMC.List.ORTA@mail.mil
 

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