Technologies Available for Licensing
THERAPEUTIC TREATMENT AND PREVENTION OF INFECTIONS WITH A BIOACTIVE MATERIAL(S) ENCAPSULATED WITHIN A BIODEGRADABLE-BIO-COMPATIBLE POLYMERIC MATRIX
Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer having a molar composition of lactide/glycolide from 90/10 to 40/60, which may contain a pharmaceutically-acceptable adjuvant, as a blend of uncapped free carboxyl end group and end-capped forms ranging to ratios from 100/0 to 1/99.
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Inventor(s):SETTERSTROM, J.; TICE, T., JACOB, E., REID, R.; VAN HAMMONT, J.; BOEDECKER, E., JEYANTHI, R.; FRIDEN, P.; ROBERTS, D.; MCQUEEN, C.; BHATTACHARJEE, A.; CROSS, A.; SADOFF, J; ZOLLINGER, W.