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EXTRANEOUS DNA SEQUENCE THAT FACILITATES HANTAVIRUS GENE EXPRESSION

In this application is described a protective DNA vaccines against infection with HFRS- and HPS-associated hantaviruses. The vaccines were constructed by subcloning cDNA representing the medium (M) (encoding the G1 and G2 glycoproteins) into the DNA expression vector pWRG7077. Animals vaccinated with the M construct developed a neutralizing antibody response. Passive transfer experiments show that serum from vaccinated animals, when injected on days 4 or 5 after challenge, protected animals from lethal disease.


Docket:RIID 99-08

Publication/Issued No.:7,217,812

Publication/Issue Date:2007-05-15

Categories: Vaccine

More Detail:Visit USPTO.GOVExternal link

Lab:WRAIR

Inventor(s):HOOPER, J.; SCHMALJOHN, C.; CUSTER, M.


For Licensing Opportunities, please contact the ORTA at USArmy.Detrick.MEDCOM-USAMRMC.List.ORTA@mail.mil
 

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