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SYNTHESIS AND ANTIMALARIAL ACTIVITY OF PYRROLO (3,2-F) QUINAZOLINEDIAMINE DERIVATIVES

The invention relates to derivatives of pyrroloquinazolinediamine, more specifically derivatives of 7-(substituted)-7H-pyrrolo[3,2-F] quinazoline-1,3-diamines that are non-toxic and are also effective in the treatment of malaria, including P. falciparum and P. vivax strains. The derivatives are certain carbamate derivatives, succinimide derivatives, alkylcarboxamides derivatives and acetamide derivative, phthalimides, alkylamines and all other amide and imide derivatives and their 1-hydroxy analogs. The derivatives of the present invention are also soluble in common organic solvents to facilitate the purification in a large scale synthesis of the composition.


Docket:WRAIR 2004-02

Publication/Issued No.:7,253,177

Publication/Issue Date:2007-08-07

Categories: Device

More Detail:Visit USPTO.GOVExternal link

Lab:WRAIR

Inventor(s):LIN, A.; GUAN, J.; ZHANG, Q.; SKILLMAN, D.


For Licensing Opportunities, please contact the ORTA at USArmy.Detrick.MEDCOM-USAMRMC.List.ORTA@mail.mil
 

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