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LARGE-SCALE PRODUCTION OF HUMAN SERUM BUTYRYLCHOLINESTERASE AS A BIOSCAVENGER
Disclosed herein are methods for the large-scale preparation of human butyrylcholinesterase (HuBChE) preparations from Cohn Fraction IV-4. As disclosed, the methods provide HuBChE preparations that are about 99% or more pure with recovery yields of about 60%. Also disclosed are the pharmacokinetics, safety and toxicity, stability and efficacy of the HuBChE preparations.
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Inventor(s):DOCTOR, B.; SAXENA, A.; SUN, W.; LUO, C.; TIPPARAJU, P.; KOPLOVITZ, I.; LENZ, D.; ROSS, M.