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METHOD OF DIAGNOSING OF EXPOSURE TO TOXIC AGENTS BY MEASURING DISTINCT PATTERN IN THE LEVELS OF EXPRESSION OF SPECIFIC GENES

A method of diagnosing exposure to a toxic agent comprising the steps of detecting the amount of protein/gene expression present in a sample of mammalian tissue or mammalian body fluids that has not been exposed to a toxic agent. Then the amount of protein/gene expression present in a sample of mammalian tissue or mammalian body fluids that has been exposed to the toxic agent is detected. A determination of the difference in the detected amount of protein/gene expression between the exposed and unexposed samples is made. A comparison of the difference to a library of expected protein/gene expression for predetermined toxic agents is made. Finally, an evaluation is made whether the difference indicates the exposure to a particular toxic agent. A treatment method for administering a therapeutic agent which inhibits the mechanistic pathways necessary to maintain the progression of lethal shock is also disclosed.


Docket:WRAIR 99-05

Publication/Issued No.:6,316,197

Publication/Issue Date:2001-11-13

Categories: Method

More Detail:Visit USPTO.GOVExternal link

Lab:WRAIR

Inventor(s):DAS, R.; JETT, M.; MENDIS, C.


For Licensing Opportunities, please contact the ORTA at USArmy.Detrick.MEDCOM-USAMRMC.List.ORTA@mail.mil
 

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