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PLASMODIUM FALCIPARUM CIRCUMSPOROZITE VACCINE GENE OPTIMIZATION FOR SOLUBLE PROTEIN EXPRESSION

The present invention provides novel nucleotide sequence and other constructs used for expression of novel recombinant P. falciparum circumsporozoite proteins in bacterial cells such as E. coli. Processes are provided for producing a soluble recombinant P. falciparum CSP from E. coli. Methods to produce a human-grade, highly immunogenic anti-malaria vaccine based on CSP are shown. The novel recombinant P. falciparum circumsporozoite protein by itself or in combination with other malaria antigens or adjuvants can form the basis of an effective malaria vaccine.


Docket:WRAIR 10-28

Publication/Issued No.:9,115,205

Publication/Issue Date:2015-08-25

Categories: Method,Vaccine

More Detail:Visit USPTO.GOVExternal link

Lab:WRAIR

Inventor(s):DUTTA


For Licensing Opportunities, please contact the ORTA at USArmy.Detrick.MEDCOM-USAMRMC.List.ORTA@mail.mil
 

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