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Disclosed herein are meningococcal immunogenic conjugates which can elicit immune responses against meningococcal polysaccharides (PS) from groups A, C, W-135, and Y and group B factor H binding protein (fHbp). The disclosed conjugates also exhibit bactericidal activity against meningococcal A, C, W-135, Y, B, and X serogroups. Also disclosed are improved methods for preparing conjugates, such as immunogenic conjugates, including activation of a polysaccharide with a cyanylation agent at about C.

Docket:WRAIR 12-39

Publication/Issued No.:9,427,476

Publication/Issue Date:2016-08-30

Categories: Method,Vaccine

More Detail:Visit USPTO.GOVExternal link


Inventor(s):LEE, CHE-HUNG

For Licensing Opportunities, please contact the ORTA at

Last Modified Date: 28 Aug 2019

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